itibaren Medina
It's a strip about a [pipe-smoking:] cat and a girl who worries too much. Add in various zombies (including Joseph Beuys), hipsters and paint-drinking and you've pretty much got it covered. Curiously, I found reading the comic online a little more enjoyable than reading it in book form. I can't exactly say why. Still, if you're not afraid of having to think about references occasionally - particularly applicable if you're not American - then this is definitely worth checking out. When it's good, it's superlatively so.
Traditional US private eye type story, except set in the present day and conspicuously post 9/11.